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Several key factors contribute to post-COVID IBS development: Persistent viral components in gut mucosa for months after infection Profound alterations in microbiota composition with depletion of beneficial bacteria Compromised intestinal barrier integrity leading to bacterial translocation HPA axis dysregulation stemming from pandemic-related psychological stress Iatrogenic dysbiosis from antibiotics and other COVID-19 treatments Though no COVID-specific treatment protocols exist yet, clinicians must adapt established IBS management strategies