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10.3389/fphys.2017.01076 69 NaoumP

Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants

Excessive lipid accumulation can also induce lipotoxic stress, leading to macrophage death and release of inflammatory mediators that promote necrotic core formation and plaque progression (133)

Thus, as pressure has increased from Congress and from DoD senior staff (notably USD AT&L) to improve utilization of SBIR-funded technologies, three broad areas for reform and improvement can be discerned: Topics and Planning In recent years, there has been considerable effort to include more input from acquisition into the topic selection process and to shorten the process to allow more opportunities to use SBIR for rapid insertion

NLRP3 knock-out reduced these effects, suggesting that an IL-1-dependent NLRP3/caspase-1 neuroimmune pathway is a key driver of fatigue and providing a rationale for targeting this axis therapeutically [77]

Sample size in the hundreds, follow-up of several months, prespecified primary endpoint, independent funding or at least transparent funding disclosure, replication of key findings