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Additionally, chronic inflammation inherent to IBD disrupts the mucosal architecture and impair the function of intrinsic factor receptors necessary for B12 uptake

GLP-1 receptor agonists semaglutide and liraglutide have demonstrated menstrual cycle normalization in multiple RCTs, primarily through insulin sensitization

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The debate often boils down to two campslocalized versus systemic application

Requires careful evaluation are adults with active or historical cancer (growth-promoting compounds require oncology-history review), significant cardiovascular disease, multiple medications requiring interaction screening, or pituitary conditions for growth hormone secretagogues