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5.5 Divergent roles of HO-1 in ferroptosis: between protection and promotion Although numerous studies have suggested that HO-1 may exert neuroprotective effects in VaD by regulating ferroptosis, an in-depth analysis of the existing literature reveals that the findings are not entirely consistent

Consequently, these events result in diminished sperm production, interruption of hormone synthesis in the testes, and compromise of the blood testis barrier in Sertoli cells (Zhu et al., 2022)

EPIC: A tool to estimate the proportions of different cell types from bulk gene expression data

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In its role as a redox buffer, GSH is conjugated to reactive Cys of endogenous proteins, inducing conformational changes in the substrate proteins, and effecting a signaling cascade that evokes biological responses (Wouters et al., 2011)