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Methionine can be further activated and converted into SAMe, a crucial substrate that regulates methylation

ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins

Dysregulation of iron metabolism in COVID-19-related PD Iron metabolism impairment, a significant contributor to PD [91, 92], has been extensively established in a significant fraction of COVID-19 patients in response to SARS-CoV-2 infection [93,94,95], which corresponds with the risk of severe and fatal COVID-19 illness

High intake of fructose, a sugar found in sugar-sweetened soft drinks and fruit juices (apples and oranges)

In cell lines selected for the resistance to topoisomerase II-inhibiting drugs the activity or the quantity of this enzyme are reduced [54]

Meanwhile, the latest review paper also emphasized the correlations between neuroinflammation and energy metabolism, focusing on the inflammatory cytokines and the activation of immune cells, extend to energy metabolism dysregulation and neural cell damage (14)