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Functional, imaging, and histological outcomes demonstrated that treated animals recovered fully, while untreated controls experienced permanent impairment

Pan-cancer analyses confirmed the cuproptosis-related gene FDX1 as an immunotherapy predictor and prognostic biomarker

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The conformational changes in IGF-IR create docking sites for its substrates, such as Shc and InsR substrates (IRS), which relay the signaling to downstream effectors including PI3K, MAPK, and STAT3

In addition, mRNA levels of pro-inflammatory genes, such as Ccl2 , iNOS , TNF, and IL-1 , were markedly downregulated in eWAT of HFD-fed Ssu72 aKO mice, with a declining trend of IL-6 (Fig

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