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Accordingly, estimations showed that contaminated pistachio nuts remarkably affected the global market of this valuable nut and ignoring the presence of AFs in these samples will increase the health risks of these mycotoxins for target exported/imported locations (114, 115)

J Neural Transm Suppl 59:133154 Aliev G, Smith MA, Seyidov D, Neal ML, Lamb BT, Nunomura A, Gasimov EK, Vinters HV, Perry G, LaManna JC et al (2002) The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimers disease

In general, under physiological conditions, substances can cross the BBB through five pathways, including passive diffusion, carrier-mediated transport, adsorptive-mediated transcytosis, adsorptive-mediated transcytosis, and efflux pumps[31, 32] (Fig

(2023b): Doorenweerd C, San Jose M, Geib S, Barr N, Rubinoff D, 2023

Health 8 , e180e190 (2020)

However, in a more recent randomized, placebo-controlled study in 102 subjects, daily supplementation with 600 mg of lipoic acid (+/- 800 mg of vitamin E [-tocopherol]) for 16 weeks had no effect on fasting blood glucose, fasting blood insulin, or a measure of insulin resistance called the homeostatic model assessment of insulin resistance (HOMA-IR) index (59)