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On the one hand, excessive ROS generation is involved in the process of chondrocyte growth inhibition and apoptosis promotion through signaling pathways, such as PI3K/AKT and p38 pathways (238, 239)

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The species-specific constants can be obtained as the product of total species concentration and the relative abundance of the respective microspecies

however, T594 did not form a hydrogen bond with the N atom of the C597 peptide bond (4.1 ) (Figs 4D, S6A-S6B), consistent with the absence of electron density for the final two amino acids, suggesting subunit asymmetry arising from the hydrogen bond interaction of T594

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A microfiltered fraction enriched with lactosylceramide (44.3%) was shown to induce caspase-independent cell death, indicated by externalization of phosphatidylserine, elevated DNA fragmentation, and a reduction in mitochondrial membrane potential in SW480 cells