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Preclinical models demonstrate that these compounds reduce reactive oxygen species, stabilize mitochondrial membrane potential, enhance mitophagy, and activate NRF2 dependent transcription, which translates into attenuation of ASD like behaviors in VPA, propionic acid, maternal immune activation, and BTBR paradigms (Yang et al., 2020

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Kaira K, Sunose Y, Arakawa K, Ogawa T, Sunaga N, Shimizu K, et al

The challenge, as we will see in the clinical evidence section, is translating that theoretical appeal into measurable real-world results at a magnitude that matters