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Further research is required to optimize the inducing dose and to discover models that can cover the full scope of AD pathogenesis

Ransohoff RM (2016)

Benjamin J, Makharia G, Ahuja V, et al

irAEs led to discontinuation of NIVO in the remaining 4 patients

A recent report documented that pharmacologic accumulation of ceramide resulted in disruption in ETC and ROS production in human neurons (Kennedy et al., 2016)