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Case 4 : NAC 2400 mg/day helped resolve severe skin-picking, though overall irritability remained stable (ABC-I: 37 to 36)

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showed that the altered function of Mn-dependent glycosyltransferase led to colon barrier dysfunction and inert inflammation in an SLC39A8 A391T mouse model, suggesting that reduced intestinal barrier integrity is the mechanism underlying this pleiotropic effect 45

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