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JHU083 JHU083 is a prodrug form of L-DON designed to be cleaved by tissue proteases and other enzymes in the cancer, thereby limiting its effects on other organs [87, 102] (Fig

The substrates for these reactions are both endogenous (intrinsic) and exogenous (xenobiotics), being mainly electrophiles, Michael acceptors, epoxides, electron-withdrawing structures and carbonyls, which are able to react through nucleophilic additions with GSH

explored the therapeutic potential of PDA NPs conjugated with an AMP and further coated with a macrophage membrane for targeted treatment of IBD via ROS scavenging and gut inflammation targeting (Fig

Gastrointestinal symptoms in diabetes: prevalence, assessment, pathogenesis, and management

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