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Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with amyotrophic lateral sclerosis is reversed by N-acetylcysteine

Hyperglycemia and hyperlipidemia can induce morphophysiological changes in rat cardiac cell line

The most common form of ALS is sporadic (sALS), with no known etiology, accounting for nearly 90-95% of all the cases, while the remaining 510% of the cases are inherited (Familial ALS-fALS), and frequently associated with an earlier age of onset [2, 7]

Thomas JP, Geiger PG, Maiorino M, Ursini F, Girotti AW

TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content

Most chronic diseases of the CNS are associated with loss of function of astrocytes, and such loss of function is emerging as a leading mechanism of disorder-related neurological dysfunctions ranging from mild changes in synapse regulation to potential overt neurotoxicity in extreme cases