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doi: 10.1016/j.freeradbiomed.2018.02.009 112 WillisBCLieblerJMLuby-PhelpsKNicholsonAGCrandallEDDu BoisRMet al

The framework above collectively called the Five Core Pillars leave zero analytical or biological blind spots

Study Duration: Four to six weeks

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[Total references: 271

To counterbalance this pro-oxidant state, KRAS-mutant cells upregulate antioxidant systems, particularly the System x_c glutathioneGPX4 axis, to prevent ferroptotic collapse