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Experimental approach (biological evaluation) In vitro enzyme bioassay The inhibitory activity of selected hits against GLO-I was assessed in vitro using recombinant human GLO-I (rhGLO-I) 34,35

Animal research shows high sucrose intake harms hippocampal memory, reduces neurogenesis, and increases oxidative stress, likely due to elevated MAO (monoamine oxidase) activity, decreased acetylcholine via cholinesterase upregulation, and excess reactive oxygen species (ROS) [8]

Acts at GHRH receptors in pituitary cells, stimulating GH secretion via intracellular second messenger pathways.- Promotes vesicle fusion and GH release into circulation, mimicking natural hormone signaling

Seyedin SN, Schoenhals JE, Lee DA, Cortez MA, Wang X, Niknam S, Tang C, Hong DS, Naing A, Sharma P, Allison JP, Chang JY , Gomez DR, Heymach JV, Komaki RU, Cooper LJ, Welsh JW

Manfaat ini berasal dari senyawa theobromine dan theophylline yang dapat melebarkan saluran napas, sehingga bisa mengurangi gejala asma

Moreover, artesunate regulates autophagy and ferroptosis by inhibiting STAT3 activation in nonHodgkin lymphoma (U2932, SU-DHL4, and Jurkat) cells [127]