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It appears to regulate neurotransmitter levels, inflammatory pathways, neuroplasticity, excitotoxicity, and disturbances in the hypothalamus-pituitary-adrenal (HPA) axis (466)

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Evaluation of phosphorus and non-phosphorus neutral oligonucleotide backbones for enhancing therapeutic index of gapmer antisense oligonucleotides

IGF-1 signaling influences immune cell development and function in research models, and LR3 has been used to probe these effects without the complicating IGFBP biology that would confound native IGF-1 experiments