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The Role of OATPs in the Uptake of HMCDs This assertion for the involvement of OATPs is reasonable as hypoxia triggers the activation of HIF1-alpha (HIF1), which promotes OATP expression (70)

Amino acid metabolic alterations, particularly upregulation of indoleamine 2,3-dioxygenase 1 (IDO1) and arginase-1 (ARG1), result in kynurenine accumulation and L-arginine depletion, synergistically suppressing T cell function while reinforcing MDSC activation [131]

Bernstein et al., 2016

Additionally, it plays a role in treating anemia and protecting eye health

10.1016/j.foodres.2018.02.003 Food Res Int

9 More than 80% of hepatocytes are vacuolated and lipid filled on cytology