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Due to the localization of QSOX in the Golgi and secretory granules, its function may be to ensure disulfide integrity during late-stage maturation and secretion, as well as formation of larger complexes after secretion ( As a whole, oxidative foldingwhether forming or reducing disulfidesconstitutes a major burden for the cell, particularly in cell types with high secretory loads

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Monitoring: Follow fracture healing with serial X-rays (typically 2-4 week intervals standard care)

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