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Description

Glutathione combats this stress by donating electrons to neutralize free radicals

J Gastroenterol Hepatol 2009;24:166976

Collectively, these results demonstrate that DLBCL cells, regardless of subtype, exhibit profound sensitivity to ferroptosis induction via small molecule GPX4 inhibition, and that this vulnerability is specific to malignant B-cells, supporting ferroptosis as a selective and mechanistically distinct strategy for therapeutic intervention in aggressive lymphomas