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Development and optimisation of alternative methods and approaches Main gaps identified: high rate of misleading/false genotoxic positives Existing in vitro methods, whilst having a high sensitivity (and thus low false negative rate), have a relatively low specificity and thus high rate of false (misleading) positive results, which typically has led to unnecessary follow-up testing in vivo for the confirmation of these results

10.1161/hypertensionaha.118.11874 131 MeeranM

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In light of the lackluster clinical results, the companys shares plunged to the lowest its been since the 1980s

The reasoning of the use of kidney cells in the experiments is generally attributed to the formation of cysteine-conjugates in liver followed by transport to the kidney (Correia et al

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