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[7] Commonly observed adverse effects include transient injection-site discomfort, breast tenderness, nausea, fluid retention, and mild mood fluctuation, whereas rarer but serious events encompass venous or arterial thromboembolism, gallbladder disease, significant elevation of blood pressure, and hormone-sensitive malignancies such as endometrial or breast cancer

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Post-surgery, physical therapy is critical to regain strength, flexibility, and full range of motion in the knee

130 In addition, PTEN participates in Wnt signalling by working with -catenin to regulate normal brain growth