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Researchers attribute these observed effects to Semaxs interaction with CNS signaling pathways rather than to any hormonal mechanism, distinguishing it from the parent ACTH molecule from which it was derived

Austin C, Boehm M, Tooze SA (2002) Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3

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2. Hydration architecture (optical smoothing)