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(1)), through the alternate reduction and re-oxidation of Cu 2+ [44]

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1 This ground-breaking study showed that the gene therapy cell product (betibeglogene autotemcel or beti-cel) led to transfusion independence in most treated patients (16/18, 89%), all of whom had genotypes that are associated with severe -thalassemia (i.e., 0 / 0 , 0 / IVS1-110 , IVS1-110 / IVS1-110 )