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Women with epilepsy who are pregnant or who plan to become pregnant should not be treated with valproate unless other treatments have failed to provide adequate symptom control or are otherwise unacceptable

96 MeiS.ChenX

This is particularly crucial for the estimated 30-40% of the population who carry genetic variations in the MTHFR gene

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CDS: 236-1618) SEQ ID NO: 146human TBXAS1 isoform 2 amino acid sequence (NP-112246.2) SEQ ID NO: 147 humanTBXAS1 transcript variant 3 cDNA sequence (NM-001130966.2