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Glutathione plays a role in protecting cells from oxidative stress and supporting the bodys natural detoxification processes

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This mitochondrial dysfunction also triggers the release of mitochondrial DNA, ROS, cytochrome c, and other damage-associated molecular patterns (DAMPs) into the extracellular space, where they act as alarmins, activating microglia and astrocytes via particular receptors like TLR4, TLR9, P2X7R, and RAGE, among others [60]

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In contrast R proteins bind cobalamin less avidly and undergo proteolysis when they come into exposure to the more alkaline environment of the small intestine (SI) (72)