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These studies found structural and functional defects in the 26S and 20S proteasomes, with a significant loss of the alpha subunit of the 20S proteasome, a loss of its enzymatic activity, and a significant decrease in the regulatory function of the 19S particles [128, 134, 135]

The cellular concentration of GSH, therefore, is regulated by a complex process of precursor amino acid transport across cell membranes, intracellular synthesizing enzymes, feedback regulation, and intracellular GSH complexing via conjugation of GSH with a variety of electrophilic compounds through GSH transferase reactions

[11] For retinol, a systematic review identified it as the most clinically investigated retinoid derivative, though a separate systematic review specifically of OTC retinol products noted methodological limitations in much of the available evidence

Free Radical Biol Med 30(11):11911212