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Furthermore, the deletion of Bmal1 in the brain induced apoE expression (inhibiting, e.g., astrocytic clearance of A [73]), potentially elucidating how circadian disruption may increase A burden in the brain

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For example, DHI, composed of Salvia miltiorrhiza and Carthamus tinctorius in a 3: 1 ratio, can comprehensively alleviate CI/RI in rats by upregulating mitochondrial dynamics-related proteins such as Mfn1, Mfn2, and OPA1 and downregulating apoptosis-related pathway proteins such as Cyt c, Apaf1, Bax, Caspase-3, and Caspase-9 (Du et al., 2023)

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