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High activity of NNMT is also correlated with lower levels of glucose transporter 4 (GLUT4), which is vital for glucose uptake from the bloodstream into fat and muscle cells

Cancer Res 52, 5391-5394

They found that it wasnt possible to determine a clear lower limit for which any of these biomarkers can reliably indicate B12 deficiency, but that daily intakes above 4.0 g appear to have no additional benefit