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oxidation of iodide, iodination of tyrosine residues of thyroglobulin (Tg), and the oxidative coupling of iodinated tyrosine residues to generate Tg-bound TH, are catalyzed by the enzyme thyroid peroxidase (TPO), which is located in the apical membrane of the thyrocyte generating hydrogen peroxide (H2O2) as a substrate [61, 62]

[DOI] [PubMed] [Google Scholar] 130.Nataraj J., Manivasagam T., Thenmozhi A.J., Essa M.M

T.LeeW.et al (2006)

Luo L, Liu D, Tang C, Du J, Liu AD, Holmberg L, Jin H

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Conclusion FDA warning letters provide a clear lens into systemic gaps, shifting enforcement priorities, and the standards that define operational excellence