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Overall, a vast amount of ROS is produced via various chemical reactions

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Finally, a mouse model study has demonstrated that, in response to niacin, the G-protein coupled receptor, hydroxycarboxylic acid receptor-2 (HCAR2) on monocytoid cells and macrophages leads to suppression of inflammatory responses and increased cholesterol efflux (Lukasova et al., 2011)

Most clinical trials have used a 500 mg dose taken twice a day