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UConn Health has an excellent environment for bringing research to the bedside. This work was supported by the National Institutes of Health, National Institute of Neurological Diseases and Stroke, National Institute of Allergy and Infectious Disease, Race to Erase MS, and the American Heart Association.

10.1021/acschemneuro.5b00159 294 Wechsler-ReyaR

The board says that Johnson has dedicated much of his career to public education and spent four years as the superintendent of Hamilton County Schools

Adding cagrilintide to tirzepatide Theoretical protocol (not clinically studied): If on tirzepatide 10-15mg: Stable on tirzepatide for 4+ weeks Continue tirzepatide at current dose Add cagrilintide 0.6mg weekly Standard cagrilintide titration to 2.4mg Rationale: Tirzepatide is dual GIP/GLP-1 (very powerful alone) Adding amylin pathway could theoretically enhance No clinical data on this combination Uncertain if additional benefit over tirzepatide alone Concerns: GI side effects may be severe (both slow gastric emptying) Tirzepatide already produces 15-22% weight loss alone Unclear if cagrilintide adds meaningful benefit Expensive combination Verdict: Wait for clinical data

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Changes in the expression of claudins in active ulcerative colitis