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While I usually recommend the methylated version of B12 (such as the one by Pure Encapsulations), individuals with the COMT genetic SNP may benefit more from the hydroxy- or adeno- forms of B12

and the production of red blood cells and cells of the immune system

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Inflammation Reduction Eventually B12 decreases widespread inflammation, but initially oxidative stress and inflammatory flares may worsen temporarily from cleansing reactions

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Vital Sign Monitoring: Regular monitoring of vital signs, including blood pressure, heart rate, and laboratory values, enables nurses to assess the effectiveness and safety of HRT