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Nicotinamide is converted into the essential co-enzymes Nicotinamide Adenine Dinucleotide (NAD) and Nicotinamide Adenine Dinucleotide Phosphate (NADP)

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One study evaluating 22 cats retrospectively suggested that iridium-192 brachytherapy might also be useful as adjuvant treatment (Bloch et al., 2020), but larger prospective studies are necessary

Ethics declarations Acknowledgements This work was undertaken as part of UK Biobank project application ref 56653 Pharmacogenomics to improve drug efficacy and safety