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NLRP3 activity is regulated by sirtuin 2 (SIRT2), an NAD + -dependent deacetylase [48], and during aging, levels of NAD + decrease, resulting in reduced sirtuin activity [49]

Although Tim-3 is a reliable marker of terminal exhausted T cells, its deficiency dampens the primary and secondary CD8 T cell responses during experimental Listeria monocytogenes infection [37]

More research needs to be done to determine whether vitamin D is beneficial for psoriatic arthritis patients

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