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Clinical decisions based on such incorrect laboratory test results may lead to patient harm due to inappropriate diagnosis and treatment

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Indeed, the generation of the oxalate metabolite is one of the few features distinguishing oxaliplatin from cisplatin, and has been proposed as one mechanism accounting for the differences in clinical presentationmost notably the presence of cold-induced neuropathy after treatment with oxaliplatin, but not cisplatin

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Nonetheless, cancer cells under sustained and increased levels of ROS may overwhelm ROS detoxifying capacity and fail to adapt to further oxidative insults, eventually triggering cell death [5, 7]