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Randomization was conducted using an interactive web response system, assigning participants in a 6:1 ratio to one of several treatment arms: once-weekly subcutaneous Cagrilintide administered in doses of 0.3, 0.6, 1.2, 2.4, or 4.5 mg, once-daily liraglutide 3.0 mg, or a volume-matched placebo

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3a, we placed a guide cannula into the lateral ventricle for the administration of either TAT or TAT-DAT NT peptide, whereas a microdialysis cannula was implanted into the nucleus accumbens core for the collection of dialysates