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Psoriasis patients with diabetes type 2 are at high risk of developing liver fibrosis during methotrexate treatment

Dysfunction in key components of this network leads to the disruption of Cu homeostasis, resulting in fatal disorders such as Wilson disease, which is caused by mutations in the hepatic Cu efflux transporter ATP7B

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Further examination with Rev-erb knockout mice, indicated increased basal nuclear factor B (NFB) and enhanced hippocampal neuroinflammatory reactivity after inflammatory challenge (Griffin et al., 2019) providing further evidence of the role and importance of circadian clock regulation on immune function

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Therapeutic approaches to address copper ion metabolism abnormalities and the associated cardiovascular diseases Despite high levels of research into the understanding of the role of copper physiologically and pathophysiologically, there remain uncertainties regarding the accurate measurement of copper levels and the long-term effects of copper exposure on cardiovascular health (118)