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Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease

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Think of them as part of the support crew that makes the real work easier

Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1

AOD-9604 Research Applications & Key Findings Metabolic and Obesity Research Weight Loss and Fat Reduction Studies Initial clinical trials in obese adults showed promising results, though later studies revealed limitations