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It was shown that in some cells direct inhibition of glutamate cysteine ligase (GCL) by BSO may upregulate factors involved in other antioxidative pathways (e.g

doi: 10.1177/08903344211058374

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Moreover, oxidative damage to mitochondrial DNA (mtDNA) results in the release of mtDNA into the cytosol, where it triggers Toll-like receptor 9 (TLR9) and inflammasome activation, leading to further production of pro-inflammatory cytokines and recruitment of immune cells 67

Expression and characterization of recombinant bifunctional enzymes with glutathione peroxidase and superoxide dismutase activities

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