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449,450 The main lesions in glaucoma increased intraocular pressure, vascular ischemia, and hypoxia in the optic nerve head

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Confocal images were acquired with 405 nm laser/418495 nm filter and 488 nm laser/499615 nm filter

In Pgam5 -deleted mice, it counterproductively promoted mitochondrial fusion, leading to intracellular ROS accumulation as well as oxidative stress, thus accelerating RPE cell senescence, in which the IRF/IFN- pathway was also observed, which may be related to cell senescence

Circ Res 136:13061334

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