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This effect is mediated through its histone deacetylase (HDAC)-inhibitory activity

doi:10.1007/s10924-020-01826-4 43

Short-chain fatty acids and thyroid hormone interact in regulating enterocyte gene transcription

doi: 10.1186/2040-2392-4-42 260 ParrachoHMBinghamMOGibsonGRMcCartneyAL

Increasing protein intake during weight loss reduces liver fat, but Western high-protein dietary patterns may exacerbate metabolic disorders, suggesting a bidirectional effect [166,167]

To safely use it in a clinical setting, it needs to be started slowly, with personalized patient education, and metabolic indicators like HbA1c, fasting glucose, and lipid panels need to be closely watched to weigh the benefits against the risks