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In vivo studies in C57BL/6 mice using ethanol and CCl to induce hepatic damage demonstrated that buckwheat extracts, as well as isolated rutin and quercetin, significantly reduced proinflammatory cytokine levels and oxidative stress markers, while suppressing mast cell activation [20]

doi:10.1038/nrd4333

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As a result, prophylactic treatments for migraine that target brain energy metabolism, including riboflavin, coenzyme Q10, alpha-lipoic acid (ALA), and ketogenic diet (KD), have gained increasing attention (Table 1)

Neurobiol Dis 132:104570

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