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Patil and Mitra (2026) identify tongue pigmentation as a bedside marker for the condition, and treating the adrenal insufficiency is the pathway to addressing the pigmentation at its source

In the ferroptosis-related pathways, butyrate modulated iron homeostasis by increasing the recruitment of Fe 2+ in lysosomes and significantly decreasing the expression level of SLC7A11 protein [47]

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It consists of three amino acids cysteine, glutamic acid and glycine