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Notably, although gcs-1 induction is impaired in CSN-deficient animals (Figures 3A,B, 2B upper panel), the high basal gcs-1 expression and increased expression of other phase 2 detoxification genes, e.g., gst-7 (Figure 2B lower panel, see Additional file 2: Figure S5), is sufficient to confer increased oxidative stress resistance (Figures 2C and 3C) [17]

Another potential therapeutic effect of curcumin mediated by its effect of TGF- is anti-tumor activity

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WARNINGS: Patients with early Leber's disease (hereditary optic nerve atrophy) who were treated with cyanocobalamin suffered severe and swift optic atrophy

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The metabolic control of autotrophic response to light and coupling between autotrophs and heterotrophs have been studied throughout diel cycles, focusing on photosynthetic rates, primary production, and heterotrophic bacterial activity 23,24