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Altogether these results indicated that nuclear GSTP restrained HMGB1 cytoplasm translocation through preventing the interaction between cPKC and HMGB1 and attenuating the interaction between HMGB1 and CRM1

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Characteristics of the study population BAL fluid samples were obtained from 23 HC, 32 mild-moderate asthma (M/M), and 43 severe asthma (SA) subjects (Table 1) recruited through either Severe Asthma Research Program 3 (SARP3) (HL-109152) or Immune Mechanisms of Severe Asthma (IMSA) (AI-06684)