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They are biologically plausible, and some early studies are worth following

Effects of creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin-A pilot clinical, histologic, and ultrastructural study

doi: 10.1530/JOE-13-0477 64 ZhaoYXiaoXFrankSJLinHYXiaY

Let's break down what you can expect when using GHK-Cu before and after for fine lines and wrinkles

The 2004 Bissett study in International Journal of Cosmetic Science used twice-daily 5 percent niacinamide for 12 weeks in 50 women aged 40 to 60, documenting significant reductions in fine lines, hyperpigmentation spots, blotchiness, and yellowing [13]