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For example, if a generic drug or plasma-derived product was currently in shortage from October 1, 2021 through December 15, 2023, CMS would apply an applicable percent reduction of 75 percent for the applicable period beginning October 1, 2022 and ending September 30, 2023, followed by a 50 percent reduction for the applicable period beginning October 1, 2023 and ending September 30, 2024, even if such drug did not meet the definition of a Part D rebatable drug or there was no rebate amount owed to which to apply the reduction

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It has been described in publications that an analogue of this domain, AOD9604, can increase lipolytic sensitivity and affect the expression of receptors beta-3 adrenergic in adipose tissue, and increase fat oxidation and energy expenditure in animal models

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