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The terminal hydroxyl group forms hydrogen bonds with the side chains of Gln72 and Gln164, and its replacement with an amine would significantly weaken the binding affinity

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10.1002/biof.155 181 RamezaniM.KomakiA.Hashemi-FirouziN.MortezaeeK.FarajiN.GolipoorZ.et al

We see that diabetes is not only a topical issue it is a growing one

Base excision repair and nonhomologous end joining are involved in repairing these damages 3,4

Immunohistochemical analysis of drug resistance-associated proteins in ovarian carcinomas