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In metabolic disease, nutrient overload and ER stress elevate H 2 O 2 /O 2 , coupling lipotoxicity to ferroptotic risk when labile iron expands (Schieber and Chandel 2014)

erinaceus on the quality of murine gut microbiota and found a change in the relative abundance of different bacteria depending on the age of the mice used for the microbiota analysis

By transferring or transplanting exogenous healthy mitochondria to replace damaged ones, cellular energy metabolism can be restored, neuronal survival improved, and neurological function recovered, offering a multidimensional therapeutic strategy for IS

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With aging, multiple structural and functional alterations such as decreased cerebrovascular pulsatility, reduced aquaporin-4 polarization on astrocyte end feet, and impaired perivascular cerebrospinal fluid exchange significantly reduce glymphatic efficiency