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Raabe OG

10.1038/nature10956 Nature 31 LiH.FischleW.WangW.DuncanE

As previously observed 11,23,26,58 , we induced sphere formation by stimulation of c-MET positive GIC models with HGF only in the absence of EGF and FGF supplementation (Supplementary Fig

Zhang et al., 2023a)

This is due to the limited availability of oxaloacetate for oxidation in the tricarboxylic acid (TCA) cycle in hepatocytes because of its consumption during concurrent gluconeogenesis

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